THE IMPORTANCE OF REGULATION DIGESTIVE SYSTEM – BRAIN INTERACTIONS ON PREVENTION INSULIN RESISTANCE AND FATTY LIVER

Introduction: Obesity, insulin resistance (IR) and fatty liver (FL) related to modern lifestyle are getting epidemic characteristics and present the most important world public health problem. Obesity, FL and IR are basic parts of metabolic syndrome. Metabolic syndrome is caused by excessive consumption of high-calorie food, chronic stress and unhealthy eating behavior. Current research shows that the digestive system with close realationship with brain has central role for keeping entire health and plays a fundamental role in pathogenesis of insulin resistance and fatty liver, but and many other diseases. Aim of the work: The aim of the paper is to evaluate and summarize new knowledge about relationship between the digestive system and the brain and how disregulation of interaction among them and eating behavior can influence on development IR and FL. Next aim of the work is to find evidence of positive effect of implementation new recommendations for healthy eating behavior, the current dietary and physical activity guidelines on prevention insulin resistence and fatty liver. Results: Current science has shown that food, eating habits and digestive system-brain relationship have a strong and decisive influence on patogenesis insulin resistance and fatty liver. Choosing healthy personal diet and healthy eating habits with a healthy lifestyle gives the opportunity to prevent insulin resistence and fatty liver, cardiovascular diseases, diabetes mellitus and many other diseases Conclusion: Better understanding of new key mechanisms of development insulin resistance and fatty liver lead to the development new therapeutic dietary and nutritional approaches. IR an FL have asymptomatic clinical course, so primary prevention and screening in early childhood are the best way to prevent the beginning and expansion of diseases. Current treatment needs to be based on the principles of personal medicine and focused on healthy lifestyles including nutrition and physical activity.