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M. Tarabichi, I. Martincorena, M. Gerstung, A. Leroi, F. Markowetz, S. Dentro, I. Leshchiner, C. Jolly, K. Haase, J. Wintersinger, A. Deshwar, K. Yu, Santiago Gonzalez, Y. Rubanova, G. Macintyre, D. J. Adams, P. Anur, R. Beroukhim, P. Boutros, D. Bowtell, Peter J. Campbell, S. Cao, E. Christie, M. Cmero, Yupeng Cun, K. Dawson, J. Demeulemeester, N. Donmez, R. Drews, R. Eils, Yu Fan, M. Fittall, D. Garsed, G. Getz, G. Ha, M. Imieliński, L. Jerman, Yuan Ji, K. Kleinheinz, Juhee Lee, H. Lee-Six, D. Livitz, S. Malikić, T. Mitchell, V. Mustonen, L. Oesper, M. Peifer, M. Peto, B. Raphael, D. Rosebrock, S. Sahinalp, A. Salcedo, M. Schlesner, S. Schumacher, Subhajit Sengupta, Rui-An Shi, Seung Shin, Lincoln D. Stein, I. Vázquez-García, Shankar Vembu, David A. Wheeler, Tsun-Po Yang, Xiao-Tong Yao, Ke Yuan, Hong-Tu Zhu, Wen-Yi Wang, Quaid D. Morris, P. Spellman, D. Wedge, P. van Loo, O. Lingjærde
68 30. 6. 2017.

Neutral tumor evolution?

Williams et al. (Nat. Genet. 48:238-224, 2016) recently reported neutral tumor evolution in one third of 904 samples from The Cancer Genome Atlas. Here, we assess the reproducibility and validity of their method and the extent of positive selection in subclonal mutations across cancer types. Our results do not support observable neutral tumor evolution and uncover strong positive selection within subclonal mutations across cancers.


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