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M. Tarabichi, I. Martincorena, M. Gerstung, A. Leroi, Florian Markowetz, Stefan C. Ignaty Moritz Clemency Kerstin Maxime Jeff Amit Dentro Leshchiner Gerstung Jolly Haase Tarabichi W, S. Dentro, I. Leshchiner, M. Gerstung, Clemency Jolly, K. Haase, J. Wintersinger, A. Deshwar, Kaixian Yu, Santiago Gonzalez, Yulia Rubanova, G. Macintyre, D. J. Adams, Pavana Anur, R. Beroukhim, P. Boutros, D. Bowtell, Peter J. Campbell, S. Cao, E. Christie, Marek Cmero, Yupeng Cun, K. Dawson, J. Demeulemeester, Nilgun Donmez, Ruben M. Drews, Roland Eils, Yu Fan, M. Fittall, D. Garsed, G. Getz, Gavin Ha, M. Imieliński, Lara Jerman, Yuan Ji, K. Kleinheinz, Juhee Lee, H. Lee-Six, D. Livitz, S. Malikić, Florian Markowetz, T. Mitchell, Ville Mustonen, Layla Oesper, M. Peifer, Myron Peto, Benjamin J. Raphael, D. Rosebrock, S. C. Sahinalp, A. Salcedo, M. Schlesner, S. Schumacher, Subhajit Sengupta, Ruian Shi, S. Shin, Lincoln D. Stein, I. Vázquez-García, Shankar Vembu, David A. Wheeler, Tsun-Po Yang, Xiaotong Yao, Ke Yuan, Hongtu Zhu, Wenyi Wang, Quaid D. Morris, P. Spellman, D. Wedge, P. van Loo, Quaid D. Morris, O. Lingjærde, D. Wedge, P. van Loo
60 30. 6. 2017.

Neutral tumor evolution?

Williams et al. (Nat. Genet. 48:238-224, 2016) recently reported neutral tumor evolution in one third of 904 samples from The Cancer Genome Atlas. Here, we assess the reproducibility and validity of their method and the extent of positive selection in subclonal mutations across cancer types. Our results do not support observable neutral tumor evolution and uncover strong positive selection within subclonal mutations across cancers.


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