Cytogenetic Causes of Infertility and Recurrent Spontaneous Abortions
First trimester pregnancy loss as well as infertility is a very common issue among many couples and the main reason they investigate is their chromosomes in that case. two hundred and sixty-six couples came to Center for Genetics of Medical Faculty-University of Sarajevo, for chromosomal cytogenetic analysis due to infertility or larger number of spontaneous abortions. To each couple, karyotype has been made, using GTG technique from cultures of lymphocytes from peripheral blood. The overall incidence of chromosomal abnormalities was 15 out of 266 couples (9%). They were divided by primary diagnose as: couples with recurrent spontaneous abortions 107 and infertility couples 159. In the first group it has found chromosomal changes at four males and one female whereas in the second group it has found chromosomal changes at seven females and three males. Structural and numerical chromosomal changes did not differ from relevant updated references from other countries, and were the main cause for infertility and recurrent spontaneous abortions. This study illustrates the incidence and distribution of chromosomal abnormalities among couples with recurrent miscarriage and infertility, and how genetic testing and counseling is important for couples with an abnormal karyotype before deciding about further reproductive options.