High prevalence of blaCTX-M-15 ; first report of blaCTX-M-28, blaCTX-M-3 blaCMY, blaDHA and blaFOX producing Enterobacteriaceae causing urinary tract infections in Bosnia and Herzegovina in hospital and community settings
Objectives To investigate molecular epidemiology of extended-spectrum (ESBL) and plasmid-mediated AmpC β-lactamase and carbapenemase producing Gram-negative bacteria the cause of urinary tract infections (UTI) in in- and outpatients in Bosnia and Herzegovina (BH 57.1%) E. coli in-patient isolates were positive for the blaCTX-M-15 and one for blaCTX-M-3. AmpC β-lactamases were detected by phenotypic test in 20 (45.5%) in- and 21 (51.2%) outpatients. One in-patient strain was positive for blaCMY and two for blaDHA, whereas four outpatient strains were positive for blaCMY and one for blaFOX. Conclusion: The CTX-M-15 was most prevalent β -lactamase in the in- and outpatients. This is the firtst report of blaCTX-M-28, blaCTX-M-3, blaCMY, blaDHA, and blaFOX from B&H. Due to high resistance rates observed for gentamicin and ciprofloxacin, carbapenems remain the antibiotics of choice for the treatment of UTIs caused by β-lactamase-producing Enterobacteriaceae in this region.