Logo
Nazad
T. Pham, L. Heunks, G. Bellani, F. Madotto, I. Aragao, G. Béduneau, E. Goligher, G. Grasselli, J. Laake, J. Mancebo, Ó. Peñuelas, L. Piquilloud, A. Pesenti, H. Wunsch, F. V. van Haren, L. Brochard, J. Laffey, Fekri Abrough, Subhash Acharya, P. Amin, Y. Arabi, P. Bauer, G. Béduneau, J. Beitler, J. Berkius, G. Bugedo, L. Camporota, V. Černý, Y. Cho, Kevin P. Clarkson, E. Estenssoro, E. Goligher, A. Gritsan, S. M. Hashemian, G. Hermans, L. Heunks, B. Jovanovic, K. Kurahashi, D. Matamis, O. Moerer, Z. Molnár, E. Ozyilmaz, B. Panka, A. Papali, Ó. Peñuelas, S. Perbet, Haibo Qiu, A. Razek, N. Rittayamai, R. Roldán, A. Serpa Neto, Konstanty Szułdrzyński, D. Talmor, D. Tomescu, F. V. van Haren, A. Villagómez, A. Zeggwagh, T. Abe, Abdelrhman Aboshady, Melanie J Acampo-de Jong, Subhash Acharya, J. Adderley, N. Adıguzel, V. Agrawal, G. Aguilar, Gastón E. Aguirre, H. Aguirre-Bermeo, Björn Ahlström, T. Akbaş, M. Akker, Ghamdan Al Sadeh, Sultan Alamri, Á. Algaba, Muneeb Ali, A. Aliberti, J. M. Allegue, D. Álvarez, J. Amador, F. Andersen, S. Ansari, Yutthana Apichatbutr, O. Apostolopoulou, D. Arellano, M. Arica, H. Arıkan, Koichi Arinaga, J. Arnal, Kengo Asano, Marta Asín-Corrochano, Jesus Milagrito Avalos Cabrera, Silvia Avila Fuentes, S. Aydemi̇r, G. Aygencel, L. Azevedo, F. Bacakoğlu, J. Badie, E. B. Baedorf Kassis, Gabriela Bai, Govindan Balaraj, Bruno Ballico, V. Banner-Goodspeed, Preveen Banwarie, Rosella Barbieri, A. Baronia, J. Barrett, L. Barrot, J. Barrueco-Francioni, Jeffrey Barry, Harshal Bawangade, S. Beavis, E. Beck, Nina Beehre, A. Belenguer Muncharaz, M. Belliato, Agrippino Bellissima, Rodrigo Beltramelli, A. Ben Souissi, A. Benítez-Cano, M. Benlamin, A. Benslama, L. Bento, Daniel K. Benvenuti, L. Bernabé, A. Bersten, G. Berta, P. Bertini, Elliot Bertram-Ralph, M. Besbes, Lisandro R. Bettini, P. Beuret, J. Bewley, M. Bezzi, Lakshay Bhakhtiani, Rakesh Bhandary, K. Bhowmick, S. Bihari, Bernie Bissett, D. Blythe, Simon Bocher, Naraindath N. Boedjawan, C. Bojanowski, E. Boni, S. Boraso, M. Borelli, S. Borello, Margarita Borislavova, K. Bosma, M. Bottiroli, O. Boyd, S. Bozbay, A. Briva, C. Bruel, Andrea Bruni, U. Buehner, Pierre A. Bulpa, K. Burt, Mathieu Buscot, S. Buttera, J. Cabrera, R. Caccese, P. Caironi, Ivan Canchos Gutierrez, Nancy Canedo, A. Cani, I. Cappellini, J. Carazo, L. Cardonnet, D. Carpio, D. Carriedo, R. Carrillo, J. Carvalho, E. Caser, A. Castelli, M. Castillo Quintero, H. Castro, N. Catorze, M. Cengiz, E. Cereijo, Helga Ceunen, Christos Chaintoutis, Youjin Chang, G. Chaparro, Carmel Chapman, Simon K. Chau, C. Chavez, C. Chelazzi, J. Chelly, F. Chemouni, Kai Chen, Ariel Chena, P. Chiarandini, P. Chilton, D. Chiumello, Yvette Chou-Lie, N. Chudeau, I. Cinel, G. Cinnella, Michele Clark, T. Clark, Stefano Clementi, Luis Coaguila, Alexis Jaspe Codecido, Amy Collins, R. Colombo, J. Conde, G. Consales, T. Cook, A. Coppadoro, R. Cornejo, A. Cortegiani, C. Coxo, A. Cracchiolo, Mónica Crespo Ramirez, P. Crova, J. Cruz, L. Cubattoli, Z. Çukurova, Francesco Curto, Piotr Czempik, Rocco D’Andrea, F. J. da Silva Ramos, L. Dangers, Marc Danguy des Déserts, P. Danin, Fabianne M. N. A. Dantas, C. Daubin, Wu Dawei, C. de Haro, F. de Jesús Montelongo, D. de Mendoza, R. de Pablo, G. De Pascale, Silvia de Rosa, M. Decavèle, P. Declercq, Alberto Deicas, María del Carmen Campos Moreno, J. Dellamonica, B. Delmas, O. Demirkıran, H. Demirkiran, Tarek Dendane, R. di Mussi, C. Diakaki, Anatilde Díaz, W. Díaz, Y. Dikmen, A. Dimoula, P. Doble, N. Doha, G. Domingos, M. Dres, D. Dries, A. Duggal, G. Duke, P. Dunts, K. Dybwik, M. Dykyy, P. Eckert, Serdar Efe, S. Elatrous, G. Elay, Abubaker Elmaryul, M. Elsaadany, Hany Elsayed, S. Elsayed, M. Emery, S. Ena, Kevin A Eng, J. Englert, E. Erdoğan, P. Ergin Ozcan, Ege Eroglu, M. Escobar, F. Esen, Arzu Esen Tekeli, A. Esquivel, Helbert Esquivel Gallegos, H. Ezzouine, A. Facchini, Mohammad Faheem, V. Fanelli, M. Farina, M. Fartoukh, L. Fehrle, Feng Feng, Yufeng Feng, I. Fernández, B. Fernández, M. Fernández-Rodríguez, C. Ferrando, M. J. Ferreira da Silva, M. Ferreruela, J. Ferrier, Matias Jesús Flamm Zamorano, Laura J. Flood, L. Floris, Martin Fluckiger, Catalina Forteza, A. Fortunato, E. Frans, A. Frattari, S. Fredes, T. Frenzel, R. Fumagalli, M. Furche, M. Fusari, E. Fysh, J. L. Galeas-Lopez, L. Galerneau, Analía García, María Fernanda García, Elisabeth Garcia, P. García Olivares, J. Garlicki, A. Garnero, E. Garofalo, Prabha Gautam, A. Gazenkampf, S. Gélinotte, Domenico Gelormini, E. Ghrenassia, Angelo Giacomucci, R. Giannoni, A. Gigante, N. Glober, P. Gnesin, Yari Gollo, D. Gomaa, Rosita Gomero Paredes, R. Gomes, Raúl Alejandro Gómez, O. Gómez, A. Gómez, L. Gondim, Manuel Gonzalez, I. González, A. González-Castro, Orlando Gordillo Romero, F. Gordo, P. Gouin, Jerónimo Graf Santos, Rooney Grainne, M. Grando, Sanja Granov Grabovica, S. Grasso, R. Grasso, L. Grimmer, C. Grissom, Qing Gu, Xiang-Dong Guan, F. Guarracino, Neus Guasch, Luca Guatteri, R. Gueret, C. Guérin, E. Guérot, P. Guitard, F. Gül, Ayça Gumus, M. Gurjar, P. Gutiérrez, A. Hachimi, A. Hadžibegović, Samantha J. Hagan, Clare Hammel, Joo Han Song, G. Hanlon, S. Heines, J. Henriksson, Jean-Etienne Herbrecht, Gabriel Omar Heredia Orbegoso, A. Hermon, R. Hernández, Carmen Hernández, L. Herrera, M. Herrera-Gutiérrez, J. Hidalgo, Dianne Hill, Dagmar Holmquist, M. Hómez, Hongtao Xia, A. Hormis, D. Horner, M. Hornos, M. Hou, S. House, B. Housni, K. Hugill, S. Humphreys, L. Humbert, Stephanie Hunter, Lee Hwa Young, N. Iezzi, S. Ilutovich, V. Inal, R. Innes, Panagiotis Ioannides, G. Iotti, M. Ippolito, H. Irie, H. Iriyama, T. Itagaki, J. Izura, S. Izza, Rakhshanda Jabeen, H. Jamaati, S. Jamadarkhana, A. Jamoussi, M. Jankowski, L.Y.A. Jaramillo, K. Jeon, Seok Jeong Lee, Deepak R Jeswani, S. Jha, Liangyan Jiang, Chen Jing, S. Jochmans, Bror Johnstad, Lee Jongmin, A. Joret, Detajin Junhasavasdikul, M. T. Jurado, E. Kam, H. Kamohara, C. Kane, I. Kara, S. Karakurt, C. Karnjanarachata, Jun Kataoka, Shinshu Katayama, S. Kaushik, N. Kelebek Girgin, Kathryn Kerr, I. Kerslake, Prakash Khairnar, A. Khalid, Akram Khan, A. Khanna, R. Khorasanee, Dieneke Kienhorst, C. Kıraklı, R. Knafelj, M. Kol, N. Kongpolprom, Csaba Kopitkó, P. Korkmaz Ekren, A. Kubisz-Pudelko, Z. Kulcsar, J. Kumasawa, A. Kuriyama, F. Kutchak, E. Labarca, Françoise Labat, C. Laborda, Manuel Alberto Laca Barrera, L. Lagache, Antonio Landaverde Lopez, M. Lanspa, Valeria Lascari, M. Le Meur, Su Hwan Lee, Young Ju Lee, Jinwoo Lee, W. Lee, Jarone Lee, T. Legernaes, T. Leiner, V. Lemiale, Tiago Leonor, P. Lepper, Dahuan Li, Hongbin Li, Oleg Li, A. R. Lima, Daniel Lind, E. Litton, Ning Liu, Ling Liu, Jialin Liu, J. Llitjos, B. Llorente, R. López, Claudia Lopez, Claudia Lopez Nava, Pablo Lovazzano, Min Lu, F. Lucchese, M. Lugano, G. Lugo Goytia, Hua Luo, C. Lynch, S. Macheda, Víctor Hugo Madrigal Robles, S. Maggiore, M. Magret Iglesias, Peter Malaga, H. Mallapura Maheswarappa, Guillermo Malpartida, A. Malyarchikov
135 1. 1. 2023.

Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.

BACKGROUND Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. METHODS WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. FINDINGS Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0-4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2-6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. INTERPRETATION In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. FUNDING European Society of Intensive Care Medicine, European Respiratory Society.


Pretplatite se na novosti o BH Akademskom Imeniku

Ova stranica koristi kolačiće da bi vam pružila najbolje iskustvo

Saznaj više