Assessing the robustness of the correlation between intra-axonal T2 and axon diameter across participants
In-vivo quantification of axon diameter is an attractive and debated topic in the MRI community. The possibility to resolve submicrometric axon diameters non-invasively yields the potential to push further the boundaries in research and clinics but yet, further work is needed to better explore and validate the existing approaches to estimate the inner axon diameter. Recently, the feasibility of estimating the axon diameter from the intra-axonal transverse relaxation time has been investigated combining a diffusion-relaxation protocol and histological data. In the present study, we apply this approach in a larger in vivo population to assess variability across participants.