The serum homocysteine and lipid levels at patients with ischemic stroke and vascular dementia
The study covered 600 patients, aim of our study was to investigate serum concentration of homocysteine and lipids at patients with ischemic stroke and vascular dementia. We determined concentrations of homocysteine, creatinine and blood lipids in patients’ serum. Homocysteine concentration reading in serum was measured by AxSYM apparatus, lipids and creatinine were determined directly by DIMENSION LxR. Mean concentrations of homocysteine in patients was higher then in healthy subjects. Our results show that the concentration of HDL cholesterol was significantly lower in the patients group than in the control group. In the group with ischemic stroke, the concentration of LDL cholesterol was higher than 4.3 mmol/L in about 56% of patients, whereas in the group with vascular dementia, was higher than the upper reference value in 60 % of patients. The Pearson correlation coefficient have show significant negative difference between serum homocysteine with HDL cholesterol concentrations in patients groups for p<0.05. Our results showed that homocysteine concentration is inversely proportionate to HDL cholesterol concentration, i.e. as homocysteine concentration in serum increases, HDL concentration falls. Homocysteine concentration increases with LDL cholesterol concentration in serum of the patients with vascular dementia, which points to homocysteine impact in further atherosclerosis development.