PP.13.13: ATHEROSCLEROSIS AND OSTEOPOROSIS THE ONE DISORDER?!

Objective: The purpose of our study was to investigate the possible association between atheroslerosis and osteoporosis and ti evaluate the common risk profile for both disorders. Design and method: A clinical prospective open label study has been designed. Total of 36 patients with a severe osteoporosis were screened for atherosclerotic changes in aorta and heart valves. The 2D and 3D transthoracic echocardiography including the color doppler was performed in all subjects. The morphology of build-up calcium and functional assessment of the blood flow either as regurgitation or stenosis through the valves was estimated. The transoesophageal echocardiography was performed in a selective cases where indicated.The analysis of severety of osteoporosis and atherosclerosis was done. The cardiovascular risk profile for both disease including arterial hypertension, smoking, lipid profile, diabetes, comorbidities etc was notified. Results: All 36 patients with established severe osteoporosis had a significant atherosclerosis manifested by high calcification of mitral anulus, mitral valves and aortic valves. The severe atherosclerosis was manifested also functionally with a mitral and aortic regurgitation and stenosis. The average T-score in osteoporotic patients was -3,1 proving severe osteoporosis with a high risk for the bone fractured. The cardiovacular risk factors were the the significantly similar in atherosclerosis and osteoporosis. The arterial hypertension, smoking, high cholesterol and diabetes were the mostly presented. Conclusions: Our results indicate the common risk factor profile for both degenerative disorders, atherosclerosis and osteoporosis. The severe osteoporosis, the more severe atherosclerosis. The loss of calcium from the bones has to be stored in other tissue like aortic, coronary arteries and heart valves. The hypothesis raise from this study is whether atherosclerosis and osteoporosis is a single disease?!