P539Coronary CT angiography in women and men suspected of acute coronary syndrome in the era of hs-troponins

MBF had weaker correlation with FFR (r=0.456, p=0.0024) than CFVR. The opti- mal cut-off value of MBF to detect CFVR < 2.0 was 1.43mL/g/min, and this cut-off value could diagnose CFVR < 2.0 with 84.0% diagnostic accuracy. The optimal cut-off value of MBF to detect FFR ≤ 0.75 was 1.38mL/g/min, and this cut-off value could diagnose FFR ≤ 0.75 with 78.6% diagnostic accuracy. Conclusions: The MBF using CTP had good diagnostic accuracy to detect myocardial ischemia. In our study, MBF seems to reflect the myocardial ischemia that is nearer to CFVR than FFR. Background: The burden of coronary artery disease (CAD) in women may still be under-recognized. This might be the result of distinct pathophysiological differ-ences or disease perception by patients and physicians. In this pre-specified sub- analysis of the Better Evaluation of Acute Chest Pain with Coronary Computed Tomography Angiography (BEACON) trial, we compare the clinical effectiveness of early coronary CT angiography (CCTA) in women and men. Methods: In the BEACON-trial, we randomized 500 patients suspected of ACS (47% women) at the emergency departments (ED) of 7 hospitals to either a diagnostic strategy supplemented by early CCTA or standard optimal care (SOC) with high-sensitivity troponins (hs-troponins) available in both groups. To assess inter-actions between sex and diagnostic group we used logistic regression analysis for with a good prognosis despite risk of non-calcified plaques Background: A coronary artery calcium (CAC) score of zero does not exclude the diagnosis of coronary artery disease (CAD), particularly in symptomatic patients due to the existence of non-calcified atherosclerotic plaques. Purpose: We evaluated the prevalence of CAD in patients with a zero CAC score, as well as the incidence of major adverse cardiac events (MACE) in these patients vs. those with a non-zero CAC score. Methods: In this prospective cohort study, consecutive patients with suspected CAD underwent CAC scoring +/− coronary CT angiography (CCTA) using a 128x2-slice dual source CT scanner as part of routine clinical care in a single centre. CAC score was calculated using the Agatston method. The primary end-point, MACE, was defined as cardiac death, non-fatal myocardial infarction and/or non-elective revascularisation. Results: A total 668 of 1279 (52%) symptomatic patients with low-to-intermediate cardiovascular risk (mean age 56±12 years; 48% male) who underwent CAC scoring between November 2009 and July 2015 had a zero CAC score. Of the 619 (93%) patients with a zero CAC in whom CCTA was performed, 552 (89.2%) had normal coronaries, 52 (8.4%) had non-obstructive CAD, 11 (1.8%) had ob- structive CAD ( > 50% stenosis), and 4 (0.6%) had non-diagnostic CCTAs. Over a median follow-up period of 2.8 years (IQR 2.1–4.4 years), the incidence of MACE was 4 (0.6%) in the zero CAC cohort vs. 14 (2.3%) in the non-zero CAC cohort, Background: Parallel to advanced imaging techniques as magnetic resonance imaging (MRI) and computed tomography (CT) becoming more affordable and accessible, the diagnosis of pathologies previously considered uncommon is in- creasing. Current ESC guidelines for pulmonary hypertension (PH) recommend high-resolution CT in all patients with PH during diagnostic workup (IIa-C). Pulmonary artery aneurysms (PAA) are a rare condition and, although its our Future should include or MRI during follow-up of PAH patients to improve the diagnosis of PAA and its potentially lethal