Analysis of discrepancies of core needle biopsy and surgical specimens for accurate evaluation of hormonal receptors and epidermal growth factor receptor 2 status of invasive breast cancer patients

Breast cancer is a serious health problem. It is the most common cancer in women. The aim of this study was to estimate the concordance between ER, PR receptor and HER-2 immunohistochemistry assessment scores in pared CNB (core needle biopsy) and surgical specimens. Histological grade, oestrogen receptor (ER) status, progesterone receptor (PR) status, and human epidermal growth factor receptor-2 (HER2) status were evaluated in a blinded fashion in CNB and in surgical excision specimens. Absolute concordance rate between core needle biopsies and surgical specimens for histological grade was 50% with κ value (0,15) for ER 92% with κ value (0,79), PR 88% with κ value (0,73) and for HER2 96% with κ value (0,91). CNB can provide reliable information in evaluation of ER, PR and HER2 status in an invasive breast carcinoma. Ključne reči: breast cancer, core needle biopsy, oestrogen receptors, progesterone receptors, HER-2. Analiza odstupanja statusa hormonskih receptora i receptora za epidermalni faktor rasta 2 u uzorcima dobijenim iglenom biopsijom i hirurškim uzorkom kod obolelih od invazivnog karcinoma dojke Ljiljana Tadic Latinovic1, Zivka Eri2, Darko Jovic3, Aleksandra Salapura1, Jovan Culum3, Branislava Jakovljevic3, Ilija Baros1, Slavica Maric4 1 Department of Pathology, University Clinical Center of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia and Herzegovina 2 Canter for Molecular Genetics, Institute for Pulmonary Diseases, Sremska Kamenica, Republic of Serbia 3 Surgical Clinic “S-Tetik”, Banja Luka, Republic of Srpska, Bosnia and Herzegovina 4 International Medical CantersCentar za Radioterapiju Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina