P4-604 SMARTPHONE-BASED ASSESSMENT OF EXECUTIVE FUNCTION: ANALYSING MOTOR-RESPONSE TRAJECTORIES TO ENHANCE THE DETECTION OF PRECLINICAL COGNITIVE IMPAIRMENT

Background: Alzheimer’s disease (AD) trials now focus on preventative rather than reactive administration, meaning the identification and engagement of those at risk for dementia has never been more important. Models of Patient Engagement in AD (MOPEAD) aims to evaluate four patient engagement strategies for identifying individuals at risk of Alzheimer’s disease: online screening, an open house initiative, primary care engagement and tertiary care engagement. We present the interim analysis of patients recruited through the online-screening model. Methods: The online tool was available in five countries (Sweden, Slovenia, Spain, Netherlands and Germany) with localised marketing strategies. Participants completed the Cambridge Neuropsychological Test Automated Battery (CANTAB Recruit): delivering Paired Associates Learning (PAL) and Spatial Working Memory (SWM) tasks to assess episodic and working memory, respectively. An algorithm was then applied to automatically score participants against pre-set criteria for further diagnostic evaluation. Results: As of February 2019, the website had received 15,000 visits and approximately 1500 participants had been screened via the web-based platform on CANTAB tests, with 75% compliance. The number of participants recruited differed by country with Germany recruiting the lowest number (n 1⁄4 32) while Slovenia met the target already (n 1⁄4 400). Demographic data showed the target age range of 65-85 years old was achieved across all five countries (Females mean age 69 years (SD 4.96 years); Males mean age 70 years (SD 5.37 years)). Age-related performance changes on CANTAB tests, across gender and education met expectations. Overall, 38% of participants met the criteria for further diagnostic evaluation. For four countries, a large proportion recruited were healthy adults, thus between 60-65% of participants did not meet criteria. Conversely, in the Netherlands, 53% of participants met the criteria for impairment. These differences could be partially attributed to the localised marketing strategy. Conclusions: This interim analysis has demonstrated that older adults (65-85 years old) are willing and able to engage in web-based assessments. Furthermore, CANTAB Recruit provides an effective strategy to identify those with impairments in episodic and working memory domains. The feasibility and sensitivity of online screening for older adults at risk of Alzheimer’s disease is encouraging.