The Influence of Co-Factors and HPV Infection on the Appearance of Cervical Lesion
The cervical cancer (CC) is in the second position in the world, by incidence and mortality, and in the first place in the developing countries. According to the information from literature different risk factors are more or less significant for the development of CC. One of the most important factor for the development of premalignant and malignant cervical lesion is infection with human papillomavirus (HPV). The strongest epidemic correlation was found in connection to the age at the time of first sexual intercourse, especially prior to the age of 18, and 21. The objective of this study is to determine the influence of etiological factors (smoking, age at the time of first sexual intercourse, number of intercourses, number of partners and status of circumcision) on the occurrence of pre-malignant and malignant cervical lesions among patients with persistent HPV infection.