0
2009.
P93 CHANGES IN REWARD SENSITIVITY DURING PUBERTAL DEVELOPMENT IN RATS
elements in the resident́s cage were analyzed. Initially, the effects of ethanol (1.0 g/kg), secondly flunitrazepam (0; 0.01; 0.1; and 0.3 mg/kg) were determined in all mice and rats; subsequently, flunitrazepam or vehicle, given intraperitoneally (0; 0.01; 0.1; and 0.3 mg/kg) was administered plus ethanol 1.0 g/kg or vehicle via gavage. Results: The most significant finding is the escalation of aggression after a moderate dose of ethanol, a low dose of flunitrazepam and after flunitrazepam plus ethanol in mice and rats. Conclusion: Ethanol can heighten aggressive behavior and flunitrazepam further increases this effect in male mice and rats.