Effect of Cefazolin and Ceftriaxone on C-Reactive Protein
C-reactive protein structurally belongs to the pentraxin family, calcium-binding proteins with immune defense properties. In the serum of healthy adults and adolescents, there is less than 5 mg of C-reactive protein. Its concentration is increased in inflammatory diseases where values up to 500 mg/l can be found. The main role of C-reactive protein is complement activation and prevention of inflammation. It binds to bacteria or damaged cells and thus helps the activation of the classic complement pathway, opsonization and phagocytosis. Binding depends on calcium. Antibiotics are products of the metabolism of bacteria, fungi and molds, rarely higher plants, which in small concentrations prevent the growth and development of microorganisms or kill them. They belong to the group of antimicrobial drugs, which are used to treat and prevent bacterial infections. Cephalosporins are beta-lactam antibiotics with the same mechanism of action as penicillin, which means that they block the synthesis of the bacterial cell