Xylitol Stabilizes the In Vivo Existence of Streptococci in Heterogeneity
Abstarct Based on data published in international journals, it appears that the five carbon sugar alcohol Xylitol has high potential to provide such an alternative preventive therapy since it is equally effective regardless of bacterial antibiotic sensitivity pattern. Xylitol derivative (Xylitol phosphate) produced by the phosphorylation of Xylitol in mitis group Streptococci even in pre-competent phase blocks their two component signal transduction pathway of growth. These diplococcic Gram-positive bacteria in the pre-competent phase, inside mother’s womb and or newly born but in chain with their mothers are also affected by Xylitol phosphate. Thinning of cell wall affects the cleavage that forms at the mid-cell position during development of the competent status. This is also the junction of septal and equatorial biosynthesis of PG (cell wall biosynthesis). Therefore, the progeny still in pre-competent phase needs to be fully understood because Xylitol phosphate formed in this phase affects bacterial maturation starting from the pre-competent phase. The bacterium S. pneumoniae responsible for the increasingly high mortality rate of children from the diseases like, bacterial pneumonia, meningitis, otitis media because it has become increasingly resistant to antibiotics like penicillin and their derivatives. Even newly developed polyvalent vaccines are not very effective against this pathogen apparently for their serological variation (?) and therefore an alternative, low cost preventive therapy is immediately necessary.