Investigation of serum copeptin levels in patients with congestive heart failure
Aims: Congestive heart failure (CHF) is characterized by symptoms and signs of volume overload and tissue perfusion insufficiency and accompanied by neurohormonal activation. Copeptin is a part of pre-pro-vasopressin and synthesized in equal molar amounts with vasopressin. We aimed to evaluate the sensitivity and specificity of copeptin in indicating the diagnostic value of CHF Methods: This retrospective study included a total of 80 patients including 40 with heart failure and 40 healthy individuals. The groups were compared in terms of demographic features, laboratory findings including copeptin levels. Results: There was no statistically significant difference between the groups in terms of gender (p>0.05). Age, hypertension, diabetes mellitus, smoking were statistically significantly higher in the heart failure group compared to the control group (p<0.05). In both groups, serum copeptin levels were higher in men than in women. Copeptin levels in the heart failure group were statistically significantly higher than in the control group (p<0.05). In the heart failure group, there was a negative correlation between serum copeptin levels and age, gender, hypertension, smoking, HDL cholesterol, hematocrit, creatinine levels. Conclusion: Copeptin is a good indicator of the course of the disease in patients with heart failure.