Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m
In vivo quantitative estimation of axon diameter in the white matter could bring new tools to study the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been questioned. In this work, we explore the feasibility of bundle-specific axon diameter mapping in a context of a reproducibility study using the Convex Optimization Modeling for Microstructure informed Tractography (COMMIT) framework. Our results show that DW-MRI axon diameter mapping of the corpus callosum and of the corticospinal tract are comparable to histological reports of previous studies.