GLOMERULAR FILTRATION RATE IN EXAMINED POPULATION OF BOSNIAN POSAVINA-REGION OF BALKAN ENDEMIC NEPHROPATHY Mirna
Balkan endemic nephropathy (BEN) is chronic tubulointersticial nephritis of unknown aetiology characterized by an insidious onset and gradual progression to end stage renal disease (ESRD). Endemic regions of Bosnia and Herzegovina are Posavina and Semberija, sited at basin of Sava River. In BEN, just like in other chronic renal diseases (CKD), glomerular fi ltration rate (GFR), is assumed a marker of overall renal function. [ e aim of this study was to compare GFR in examinees of endemic and non-endemic region for BEN, and between examinees with and without risk factors for BEN within endemic region Study included inhabitants of Bosnian Posavina, out of whom () from endemic (Domaljevac) and () from nonendemic (Svilaj) village, and it was performed in two phases. [ e fi rst phase encompassed obtaining anamnestic data (demographic, personal and family history), measurement of arterial blood pressure, and urine dipstick testing (specifi c gravity, pH, proteins, leukocytes, glucose, ketones, and mycroalbuminuria). In the second phase, besides repeated urine dipstick test, laboratory blood testing and abdominal ultrasound, with special attention to urinary tract, was also performed. We have compared GFR between examinees of endemic and non-endemic regions for BEN, and between examinees with and without family burden for BEN within endemic region, using MDRD formula for calculating GFR, with cut-off value (th percentile) based on result of studies performed in European Caucasians in screening for CKD and for establishing stages of CKD in BEN. Medical was used for statistical testing. Out of total number of examined inhabitants (), examinees were included in the second phase. After exclusion of diabetic patients, () examinees from endemic and () examinees from non-endemic region remained. In the endemic region there were () examinees with and () without family burden for BEN. Overall GFR in examined groups was within physiologic range. [ ere was not statistically signifi cant diff erence in calculated GFR between examinees of endemic and non-endemic regions for BEN (Mann-Whitney test p=.; Fisher’s test p=), neither between examinees with and without family burden for BEN within endemic region (Mann-Whitney test p=,; Fisher’s test p=,). GLOMERULAR FILTRATION RATE IN EXAMINED POPULATION OF BOSNIAN POSAVINA REGION OF BALKAN ENDEMIC NEPHROPATHY Mirna Alečković1*, Enisa Mešić1, Senaid Trnačević1, Želimir Stipančić1, Damir Hamidović1, Evlijana Hasanović3 1 Department of Nephrology and Dialysis, Clinic for Internal Diseases, University Clinical Centre Tuzla, Trnovac bb, Tuzla, Bosnia and Herzegovina 2 Centre for Dialysis, Regional Hospital Orašje, Orašje, Bosnia and Herzegovina 3 Pediatric clinic, University Clinical Centre Tuzla, Trnovac bb, Tuzla, Bosnia and Herzegovina * Corresponding author