Treatment of Patients with Multiple Sclerosis by Pulse Corticosteroid Therapy at Neurologic Clinic of Clinical Center University of Sarajevo

Multiple sclerosis is autoimmune, inflammatory, demyelinating chronic disease of the CNS with degenerative disseminated changes of the white mass of brain and spinal cord. Due to its frequency, chronic course and tendency to affect younger people, it is one of the most common, the most severe and the most important neurological disease.The aim of the investigation is to make an insight into application of pulse corticosteroid therapy of multiple sclerosis at the Neurological clinic of the Clinical Center of Sarajevo University during 2005 compared to psychical disorder in patients. A modified questionnaire form was used for analyzing patient’s histories of ilness and it is routinely used at the Neurological clinic of the Clinical Center of Sarajevo University.The investigation included 34 patients who were treated at the Neurological clinic of the Clinical Center of Sarajevo University during 2005. 20 patients were female (59%), and 14 were male (41%). 40% of patients were age 40-49, 29% workers, 73% of patients had secondary school level of education, in 3 patients psychic stress was identified as precipitating factor for development of the disease. Average period of hospitalization was 17.5 days. Not a single patient quoted any psychic disorder as a disease symptom, nor in the onset or relapse of the disease. Also, following pulse corticosteroid therapy not a single patient reported any changes of psychic condition that would be important to evidence observe and treat.Conclusion: 34 patients were treated at the Neurological clinic of the Clinical Center of Sarajevo University during 2005 with confirmed diagnosis of multiple sclerosis during relapse of the disease with pulse corticosteroid therapy. There were more female patients, with secondary school level of education, with significant cognitive dysfunctions and existing depressive affect. Doctrinarian approach to the treatment of relapse with high doses of methyl-prednisolone lead to significant improvement of neurological dysfunction.