Values of fibrinogen in relation to segmental involvement of the venous system in patients with recurrent deep vein thrombosis

Introduction: The occurrence of recurrent venous thrombosis, despite adequate therapy, is still a topic of research in the scientific world. The site of thrombosis and the involvement of anatomical segments represent a significant factor in its occurrence. Aim: To correlate fibrinogen values with anatomical location and extent of verified thrombus in patients with recurrent deep vein thrombosis. Materials and methods: In the period January 2007-January 2020, 223 patients with recurrent deep vein thrombosis were analyzed. At admission fibrinogen values were taken. Results: There was no significant difference in fibrinogen values in relation to gender (p = 0.842). The difference in mean fibronogen values between proximal (n = 171) and distal (n = 27 = veins) were not statistically significant (p = 0.326). There was no difference between the average values of fibrinogen in relation to the number of segments (1 to 3) (p = 0.298). The largest number of patients (n = 132) had 2 segments affected, and fibrinogen values was 4.7 g/L (3.6-7.1 g/L). Male gender had slightly higher fibrinogen values than females, but without significance (p = 0.091). The age of the subjects did not correlate with fibrinogen values ( p = 0.569). Fibrinogen values according to vein anatomical localization were statistically non-significant (p = 0.201). Conclusion: Fibrinogen values were not proved to be an indicator of anatomical localization and segmental involvement in patients with recurrent DVT. Keywords: fibrinogen, venous thrombosis, prognosis.