Human amniotic membrane plug for chronic or persistent macular holes.
PURPOSE To report on the use of human amniotic membrane (hAM) for macular holes at two Canadian tertiary care centres. DESIGN Retrospective cohort study. SUBJECTS 22 patients with persistent or chronic macular holes. METHODS Macular hole surgery was performed by three vitreoretinal surgeons. MAIN OUTCOMES Macular hole closure with complete plugging by hAM on SD-OCT. RESULTS The closure rate was 91% (20/22, median follow-up 7 months) with no statistically significant visual acuity change overall. Complications included subretinal silicone oil (5%), choroidal neovascularization (5%), atrophy (5%), and cystoid macular edema (9%). CONCLUSIONS Anatomical success with limited visual recovery was observed.