PP.21.05: THE COMBINATION OF SELECTIVE BETA1-BLOCKER AND SELECTIVE CALCIUM CHANNEL BLOCKER THIRD GENERATION IN TREATING HYPERTENSIVE HEART DISEASE

Objective: A patient, female, 78 years of age, appears with symptoms of rapid fatigue, headache, vertigo which has progressed followed by irregular blood pressure. She has been diagnosed as hypertensive heart disease, chronic obstructive pulmonary disease (COPD), essential hypertension and supraventricular tachycardia paroxysmal in our clinic. Previously, she diagnosed as essential hypertension, coronary artery disease (CAD), COPD and atrial fibrillation paroxysmal. She was taking non selective beta blocker, angiotensin receptor blocker, iso sorbitol mononitrate (ISMN) and an inhibitor of platelet aggregation, but without any special progress. Figure. No caption available. Design and method: ECG and echocardiogram show underway hypertensive heart disease that shows a deep inverted tunnel-shaped T waves in the left precordial leads and concentric hypertrophy of the left ventricle with IVSs 1.45 mm. Ambulatory Blood Pressure Monitoring (ABPM) show unregulated hypertension stage III, JNC VIII. Spirometry confirmed moderate restrictive disease on the basis of COPD. Results: After two months, patient subjectively feels great and it confirms regulated blood pressure. Control ECG findings point to the complete regression of deep invert T waves in the left precordial leads. Control echocardiogram shows improving left ventricular compliance is verified with regression IVS thickness from 1.29 mm to the improvement of diastolic heart function. (ABPM) show regulated hypertension stage I, JNC VIII. Conclusions: In the literature there is not a lot of work in combination therapy with selective beta 1-blocker and calcium channel blocker third generation in the treatment of hypertensive heart disease. Our work shows that in the short time interval combination with these two groups of drugs can significantly contribute to the improvement of the clinical picture and objective parameters ECG and echocardiogram for hypertensive heart disease.