of Gastric Carcinoma in The Events of Helicobacter Pylori Positive Chronic Atrophic Gastritis
Th e aim of the study was to ascertain the existence of intestinal metaplasia in gastric mucosa of patients with gastric carcinoma coupled with H. pylori positive chronic atrophic gastritis and possible connection of IM with the development of gastric carcinoma. Th e paper pres- ents prospective study that included patients with gastric carcinoma and patients with chronic atrophic H. pylori positive gastritis. All the patients were subjected to gastroscopy as well as biopsy targeted at antrum, lesser curvature and corpus and at the area - cm removed from tumor lesion. Biopsy samples were sliced by microtome and stained. We analyzed pres- ence, frequency and severity of infl ammatory-regenerative, metaplastic and dysplastic chang- es in the mucosa and evaluated their prognostic value. We typed IM immunohistochemically. Th is study confi rmed responsibility of H. pylori for infl ammatory events in gastric mucosa in patients with gastric carcinoma. According to our fi ndings incomplete IM of types IIa and IIb as precancerous lesion is responsible for the development of gastric carcinoma and is as- sociated with chronic atrophic gastritis grade I and II ( of subjects, p=,, h=, p=,). Th us, the fi nding of incomplete intestinal metaplasia may be used as an indicator for early gastric carcinoma detection. Patients with patho-histologicaly verifi ed incomplete intestinal metaplasia associated with active chronic atrophic gastritis of levels I and II represent risk group for the development of gastric carcinoma of intestinal type.