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0 2009.

OF ANTENATAL CORTICOSTEROIDS AND SURFACTANT REPLACEMENT ON NEONATAL RESPIRATORY DISTRESS SYNDROME

Th e goal of this study was to determine the eff ects of antenatal corticosteroids and surfactant re- placement on the severity and frequency of Respiratory Distress Syndrome (RDS) in a cohort of premature infants born in Sarajevo, Bosnia and Herzegovina, from  to . Th e cohort con- sisted of  premature neonates with estimated gestational age between  and  weeks. Babies with IUGR, babies of diabetic mothers and babies with major congenital defects were excluded. Out of  neonates,  were treated antenatally with corticosteroids (single course of dexam- ethasone) and / were not. Th ere was no statistical diff erence (p>,) in average gestational age (, vs. , GW) and male/female ratio between investigated groups; there were signifi cant- ly more male patients (p , and mechanical ventilation. Early surfactant administration within six hours after birth appeared to be eff ective at reducing mortal- ity then later surfactant administration (p<,). In the group of babies requiring FiO≥, at the time of surfactant replacement, the mortality rate was signifi cantly higher (p<,). In conclusion, we confi rm the effi cacy of antenatal corticosteroid treatment and early surfactant treatment in a cohort of premature infants born in Sarajevo.


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