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I. Homšek, B. Kolarić, S. Ristić, Ivan M. Kolarić
1 1. 9. 1998.

Characterization of nimodipine/β‐cyclodextrin inclusion complex

One problem with many of the active substances, used today is their poor solubility in water and theirs limited bioavailability. Cyclodextrins have received considerable attention in the pharmaceutical field because of improved aqueous solubility, and chemical stability of various drug molecules through inclusion complex (1). In this study, solid dispersions are prepared by freeze dry technique in order to improve the solubility of nimodipine (NM), which belongs to the relatively small dihydropyridine group of calcium channel blocking agents. NM is practically insoluble in water. The present contribution deals with the potentiality of inclusion complexations of NM in p-cyclodextrin


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