Logo
Nazad
Shaun G. Goodman, P. Steg, M. Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Díaz, Robert A. Harrington, J. Jukema, Harvey D. White, Andreas M. Zeiher, G. Manvelian, R. Pordy, Y. Poulouin, W. Stipek, Geneviève Garon, G. Schwartz, Gregory G Ph Gabriel Deepak L Vera A Rafael Shaun G Robert Schwartz Steg Bhatt Bittner Diaz Goodman Harringto, G. Schwartz, P. Steg, Deepak L. Bhatt, Vera A. Bittner, R. Diaz, Shaun G. Goodman, Robert A. Harrington, J. Jukema, M. Szarek, H. White, Andreas M. Zeiher, P. Tricoci, M. Roe, K. W. Mahaffey, Jay M. Edelberg, C. Hanotin, G. Lecorps, A. Moryusef, R. Pordy, W. Sasiela, J. Tamby, Phil Aylward, H. Drexel, Peter Sinnaeve, M. Dilić, Renato D. Lopes, Nina Gotcheva, J. Prieto, Huo Yong, Patricio López-Jaramillo, I. Pećin, Ž. Reiner, Petr Ošťádal, S. Poulsen, M. Viigimaa, Markku S. Nieminen, N. Danchin, V. Chumburidze, Nikolaus Marx, E. Liberopoulos, P. Valdovinos, Hung Fat Tse, R. G. Kiss, Denis Xavier, D. Zahger, M. Valgimigli, Takeshi Kimura, H. Kim, Sang-Hyun Kim, A. Erglis, A. Laucevičius, S. Kedev, K. Yusoff, G. A. López, M. Alings, S. Halvorsen, Roger M. Correa Flores, R. Sy, Andrzej Budaj, J. Morais, M. Dorobantu, Y. Karpov, Arsen D. Ristić, Terrance Chua, Ján Murín, Zlatko Fras, A. Dalby, J. Tuñón, H. A. de Silva, E. Hagström, Ulf Landmesser, C. Chiang, P. Sritara, S. Guneri, A. Parkhomenko, Kausik K. Ray, P. M. Moriarty, B. Chaitman, S. F. Kelsey, Anders G. Olsson, Jean-Lucien Rouleau, M. Simoons, K. Alexander, Chiara Meloni, Robert S. Rosenson, Eric J. G. Sijbrands, John H. Alexander, Luciana Armaganijan, A. Bagai, M. Bahit, J. Brennan, Shaun Clifton, A. Devore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, P. Endsley, Arleen Eppinger, Robert W. Harrison, Connie N. Hess, M. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Bradley J. Kolls, David F. Kong, S. Leonardi, Linda Lillis, David J. Maron, Jill Marcus, R. Mathews, Rajendra H. Mehta, R. Mentz, C. Patel, S. Pereira, Lynn M. Perkins, T. Povsic, E. Puymirat, W. S. Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, M. Toma, Charlene Trotter, S. van Diepen, Matthew D. Wilson, A. Yan, Lilia B. Schiavi, M. Garrido, A. Alvarisqueta, Sonia A. Sassone, Anselmo P. Bordonava, Alberto E. Alves De Lima, J. Schmidberg, E. Duronto, Orlando C. Caruso, Leonardo P. Novaretto, M. Hominal, O. Montaña, A. Caccavo, O. A. Gomez Vilamajo, A. Lorenzatti, L. Cartasegna, G. Paterlini, Ignacio J. Mackinnon, G. Caime, M. Amuchastegui, Oscar Salomone, Oscar R. Codutti, H. Jure, J. Bono, A. Hrabar, Julio A. Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, C. Zaidman, Maria E. Giuliano, R. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, D. G. Garcia Brasca, M. B. Bustamante Labarta, S. Nani, E. Blumberg, H. Colombo, A. Liberman, V. Fuentealba, H. L. Luciardi, Gabriel D. Waisman, M. Berli, R. G. Garcia Duran, Horacio G. Cestari, H. Luquez, Jorge A. Giordano, Silvia S. Saavedra, G. Zapata, O. Costamagna, Susana C Llois, J. Waites, Nicholas Collins, A. Soward, C. L. Hii, James Shaw, Margaret A. Arstall, John Horowitz, D. Ninio, James F. Rogers, David Colquhoun, Romulo E. Oqueli Flores, P. Roberts-Thomson, O. Raffel, S. Lehman, C. Aroney, S. Coverdale, P. Garrahy, G. Starmer, Mark Sader, P. Carroll, R. Dick, R. Zweiker, U. Hoppe, K. Huber, R. Berger, G. Delle-Karth, Bernhard Frey, D. Faes, K. Hermans, B. Pirenne, A. Leone, E. Hoffer, Mathias Vrolix, L. De Wolf, B. Wollaert, M. Castadot, K. Dujardin, C. Beauloye, G. Vervoort, H. Striekwold, C. Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, F. Cools, I. Terzić, F. Baraković, Z. Midzić, B. Pojskić, E. Fazlibegović, A. Durak-Nalbantić, M. Kulić, D. Vulic, A. Muslibegovic, B. Goronja, G. Reis, Luciano Lopes de Sousa, J. C. Nicolau, F. Giorgeto, R. Silva, L. N. Maia, R. Rech, P. Rossi, M. J. A. Cerqueira, Norberto Duda, R. Kalil, A. Kormann, José Antonio M. Abrantes, Pedro Pimentel, A. Soggia, M. D. de Santos, F. Neuenschwander, L. C. Bodanese, Yorghos L. Michalaros, F. Eliaschewitz, M. H. Vidotti, P. Leães, R. Botelho, S. Kaiser, E. Manenti, D. Précoma, J. M. Moura Jorge, Pedro Silva, J. A. Silveira, W. Saporito, Jose A. Marin, G. Feitosa, L. Ritt, J. D. de Souza, F. Costa, W. Souza, H. J. Reis, Leandro Machado, J. C. A. Ayoub, G. Todorov, Fedya P. Nikolov, Elena S. Velcheva, M. Tzekova, H. Benov, S. Petranov, Haralin S. Tumbev, Nina S. Shehova-Yankova, Dimitar T. Markov, D. Raev, Mihail N. Mollov, K. Kichukov, Katya A. Ilieva-Pandeva, R. Ivanova, Maryana Gospodinov, Valentina M. Mincheva, Petar V. Lazov, Bojidar I. Dimov, M. Senaratne, James Stone, J. Kornder, Danielle Dion, Dan Savard, Y. Pesant, A. Pandey, Simon Robinson, Gilbert Gosselin, S. Vizel, Gordon Hoag, Ronald Bourgeois, Anne Morisset, Eric Sabbah, B. Sussex, S. Kouz, Paul Macdonald, Ariel Díaz, Nicolas Michaud, David Fell, T. Vuurmans, Christopher Lai, F. Nigro, Richard Davies, G. Nogareda, R. Vijayaraghavan, J. Ducas, Serge Lepage, S. Mehta, James Cha, Robert Dupuis, Peter Fong, S. Lutchmedial, J. Rodés-Cabau, Hussein Fadlallah, David Cleveland, T. Huynh, I. Bata, A. Hameed, Cristian Pincetti, S. Potthoff, Juan C. Prieto, Monica Acevedo, Arnoldo Aguirre, M. Véjar, Mario Yañez, G. Araneda, Mauricio Fernandez, Luis Perez, P. Varleta, F. Florenzano, Laura Huidobro, C. Raffo, C. Olivares, Leonardo Nahuelpan, H. Montecinos, Jiyan Chen, Yugang Dong, Wei-Jian Huang, Jian-Zhong Wang, Shi'an Huang, Zhuhua Yao, Xiang Li, Lan Cui, Wen-Hua Lin, Yue-Ming Sun, Jing-Feng Wang, Jian-ping Li, Xuelian Zhang, Hong Zhu, Dan-Dan Chen, Lan Huang, Shao-Hong Dong, Guo-Hai Su, Biao Xu, Xi Su, Xiao-Shu Cheng, Jinxiu Lin, Wen-Xia Zong, Huanming Li, Yi Feng, Dingli Xu, Xin-Chun Yang, Yuan-Nan Ke, Xuefeng Lin, Zheng Zhang, Ze-Qi Zheng, Zhu-Rong Luo, Yundai Chen, Chunhua Ding, Yi Zhong, Yang Zheng, Xiao-Dong Li, Dao-Quan Peng, Shuiping Zhao, Ying Li, Xue-Bo Liu, Meng Wei, Shaowen Liu, Yi-Hua Yu, Baiming Qu, Weihong Jiang, Yu-Jie Zhou, Xingsheng Zhao, Zu-Yi Yuan, Ying Guo, Xiping Xu, Xu-Bo Shi, Junbo Ge, Guo-Sheng Fu, Feng Bai, Weiyi Fang, X. Shou, Xiang-Jun Yang, Jian'an Wang, Meixiang Xiang, Ying-Xian Sun, Qing-Hua Lu, Rui-Yan Zhang, Jianhua Zhu, Yi-Zhou Xu, Zhong-Cai Fan, Tian-Chang Li, Chun Wu, Nicolás Jaramillo, G. Vallejo, Diana C. Luna Botia, R. Lopez, D. I. Molina de Salazar, A. C. Cadena Bonfanti, Carlos Cotes Aroca, Juan Diego Higuera, Marco Blanquicett, Sandra I. Barrera Silva, Henry J. Garcia Lozada, Julian A. Coronel Arroyo, Jose L. Accini Mendoza, Ricardo L. Fernandez Ruiz, Álvaro M. Quintero- Ossa, Fernando G. Manzur Jatin, Arístides Sotomayor Herazo, Jeffrey Castellanos Parada, Rafael Suarez Arambula, Miguel Urina Triana, Angela M. Fernandez Trujillo, M. Strozzi, S. Car, M. Jerić, M. Benčić, H. Pintarić, Đeiti Prvulović, J. Šikić, V. Peršić, D. Mileta, K. Štambuk, Z. Babić, Vjekoslav Tomulić, Josip Lukenda, Stanka Mejic-Krstulovic, Boris Starčević, J. Špinar, D. Horák, Z. Velička, Josef Stasek, D. Alan, Vilma Machova, A. Linhart, V. Novotný, V. Kaučák, R. Rokyta, Robert Náplava, Z. Coufal, Vera Adamkova, Ivo Podpera, J. Žižka, Z. Motovska, Ivana Marušincová, P. Sváb, P. Heinc, Jiří Kuchař, P. Povolný, Jiri Matuska, Steen H. Poulsen, B. Raungaard, Peter M. Clemmensen, L. Bang, O. May, M. Bøttcher
23 20. 4. 2024.

Safety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation

Abstract The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.


Pretplatite se na novosti o BH Akademskom Imeniku

Ova stranica koristi kolačiće da bi vam pružila najbolje iskustvo

Saznaj više