Chemism and the role of endocannabinoids in physiological processes
Despite being known for 5000 years, after the records of imperial Chinese doctors, cannabinoids as a subject of scientific research experienced its rise after 1964, when delta nine tetrahydrocannabinol (Δ 9 THC) by Israeli scientists was identified. This was followed by the discovery of endogenous ligand / endocannabinoids, as well as receptors CB1 and CB2. In a broader sense, endocannabinoids act as neuromodulators and immunomodulators. They are included in the various physiological processes such as: the occurrence of pain, cognition, memory formation and neuroplasticity, physical activity, respiratory processes, appetite regulation, control and heart rate, nausea and emesis, intraocular pressure, inflammatory and immune processes (antigen recognition).