Expression of estrogen receptors ( ER ) and p 53 in endometrial carcinoma and correlated with of histological type , grade and stage

Objective. The differences in immunohistochemical expression of estrogen receptors (ER) and p53 in endometrial carcinoma and correlated with of histological type, grade and stage are crucial in the planning of further monitoring and treatment of patients. Materials and methods. This paper deals with data of the patients treated for endometrial carcinoma in Public Hospitals in Travnik, gynecological department in the period from 01.01.2007. to 01.01.2013 th the sample consisted of 97 women with endometrial carcinoma, with ages ranging from 42 to 90 years (mean of 64 years). 72 cases (74.2%) were of endometrioid and 25 (25.8%) nonendometrioid carcinoma. Results. The 72 endometrioid carcinoma cases were final disease stage as follows: stage I = 29/72 (40%) and stages II, III et IV = 43/72 (60%). Markers and histological types: p53 expression was found in 10 patients (13.8%) of the endometrioid and 17 patients (68%) of the nonendometrioid endometrial carcinoma. The estrogen receptors were more frequent in the endometrioid type 44 patients (61%) with regard to 7 patients of the nonendometrioid type endometrial carcinoma. Markers and histological grade: In the 72 cases of endometrioid carcinoma, those with grade I expressed estrogen (22 out of 36 cases = 61.1%) more frequently than those with grades II and III. p53 was expressed in only 3.8% of endometrioid carcinomas. Conclusion. The different immunohistochemical profiles of endometrioid and nonendometrioid carcinomas confirm different molecular pathways in their development. The correlation of immunohistochemical findings with histological grade and clinical stage could help in predicting biologic behavior and planning treatment in patients who are diagnosed as having these tumors. 2 Sinisa Maksimovic et al.: Expression of Estrogen Receptors (ER) and P53 in Endometrial Carcinoma and Correlated with of Histological Type, Grade and Stage