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Constance H. Li, S. Prokopec, Ren X. Sun, Fouad Yousif, Nathaniel Schmitz, Fatima Gurnit Peter J. Andrew V. Paul C. Peter J. David K Al-Shahrour Atwal Bailey Biankin Boutros Campbell , F. Al-Shahrour, Gurnit Atwal, P. Bailey, A. Biankin, Paul C. Boutros, P. Campbell, David K. Chang, S. Cooke, Vikram Deshpande, B. Faltas, W. Faquin, L. Garraway, G. Getz, S. Grimmond, S. Haider, K. Hoadley, W. Jiao, V. Kaiser, Rosa Karlić, M. Kato, Kirsten Kübler, A. Lazar, Constance H. Li, David N. Louis, Adam A. Margolin, S. Martin, Hardeep K. Nahal-Bose, G. P. Nielsen, S. Nik-Zainal, L. Omberg, Christine P'ng, Marc D. Perry, P. Polak, Esther Rheinbay, Mark A. Rubin, C. Semple, D. Sgroi, T. Shibata, Reiner Siebert, Jaclyn Smith, Lincoln Stein, Miranda D. Stobbe, Kevin Thai, Derek W. Wright, Chin-Lee Wu, Ke Yuan, Junjun Zhang, Paul C. Boutros, Lauri A. Federico Adam Hiroyuki David J. Nishant Keun So Aaltonen Abascal Abeshouse Aburatani Adams Agrawal, L. Aaltonen, F. Abascal, Adam Abeshouse, H. Aburatani, D. J. Adams, N. Agrawal, K. Ahn, S. Ahn, H. Aikata, Rehan Akbani, K. Akdemir, H. Al-Ahmadie, S. Al-Sedairy, M. Alawi, Monique Albert, K. Aldape, L. Alexandrov, A. Ally, K. Alsop, Eva G. Álvarez, F. Amary, S. Amin, Brice Aminou, O. Ammerpohl, M. Anderson, Y. Ang, D. Antonello, Pavana Anur, S. Aparicio, Elizabeth L. Appelbaum, Y. Arai, Axel Aretz, K. Arihiro, S. Ariizumi, J. Armenia, L. Arnould, S. Asa, Y. Assenov, S. Aukema, J. Auman, M. R. Aure, P. Awadalla, M. Aymerich, Gary D Bader, Adrian Baez-Ortega, Matthew H. Bailey, M. Balasundaram, S. Balu, P. Bandopadhayay, R. Banks, S. Barbi, A. Barbour, J. Barenboim, J. Barnholtz-Sloan, Hugh Barr, E. Barrera, John M. S. Bartlett, Javier Bartolome, C. Bassi, O. Bathe, D. Baumhoer, P. Bavi, S. Baylin, Wojciech Bazant, D. Beardsmore, Timothy A. Beck, S. Behjati, A. Behren, Beifang Niu, C. Bell, S. Beltrán, Christopher Benz, A. Berchuck, A. Bergmann, E. Bergstrom, B. Berman, D. Berney, S. Bernhart, R. Beroukhim, Mario Berrios, S. Bersani, Johanna Bertl, M. Betancourt, Vinayak Bhandari, S. Bhosle, M. Bieg, D. Bigner, Hans-Eugen Binder, E. Birney, M. Birrer, N. Biswas, B. Bjerkehagen, T. Bodenheimer, L. Boice, G. Bonizzato, J. D. de Bono, Arnoud Boot, M. Bootwalla, Å. Borg, A. Borkhardt, Keith A. Boroevich, I. Borozan, Christoph Borst, M. Bosenberg, Mattia Bosio, J. Boultwood, G. Bourque, G. Bova, D. Bowen, R. Bowlby, D. Bowtell, S. Boyault, R. Boyce, Jeffrey H. Boyd, A. Brazma, P. Brennan, D. Brewer, A. Brinkman, Rob Bristow, R. Broaddus, J. Brock, M. Brock, A. Broeks, Angela N. Brooks, Denise Brooks, B. Brors, S. Brunak, Timothy J. C. Bruxner, A. Bruzos, Alex Buchanan, I. Buchhalter, C. Buchholz, S. Bullman, H. Burke, B. Burkhardt, K. Burns, John P. Busanovich, C. D. Bustamante, A. Butler, A. Butte, Niall J. Byrne, A. Børresen-Dale, Samantha J. Caesar-Johnson, Andy Cafferkey, D. Cahill, C. Calabrese, Carlos Caldas, F. Calvo, Niedzica Camacho, E. Campo, C. Cantù, S. Cao, T. Carey, Joana Carlevaro-Fita, R. Carlsen, I. Cataldo, M. Cazzola, J. Cebon, R. Cerfolio, D. Chadwick, D. Chakravarty, D. Chalmers, Calvin Wing Yiu Chan, Kin Chan, M. Chan-Seng-Yue, V. Chandan, S. Chanock, L. Chantrill, A. Chateigner, N. Chatterjee, K. Chayama, Hsiao-wei Chen, Jie-Ming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, A. Cherniack, Jeremy Chien, Y. Chiew, Suet-Feung Chin, Juok Cho, Sunghoon Cho, J. Choi, Wan Choi, C. Chomienne, Zechen Chong, S. Choo, A. Chou, Angelika N. Christ, E. Christie, E. Chuah, C. Cibulskis, K. Cibulskis, S. Cingarlini, P. Clapham, A. Claviez, S. Cleary, N. Cloonan, Marek Cmero, C. Collins, Ashton A. Connor, C. Cooper, L. Cope, V. Corbo, M. Cordes, S. Cordner, I. Cortés-Ciriano, K. Covington, P. Cowin, B. Craft, David W Craft, C. Creighton, Yupeng Cun, Erin E. Curley, Ioana Cutcutache, Karolina M. Czajka, B. Czerniak, Rebecca A. Dagg, Ludmila V. Danilova, M. Davi', Natalie R. Davidson, H. Davies, Ian J. Davis, Brandi Davis-Dusenbery, K. Dawson, F. M. de la Vega, R. De Paoli-Iseppi, T. DeFreitas, A. D. Dei Tos, O. Delaneau, J. Demchok, J. Demeulemeester, German Demidov, Deniz Demircioğlu, Nening Dennis, R. Denroche, S. Dentro, Nikita Desai, Vikram Deshpande, A. Deshwar, C. Desmedt, J. Deu-Pons, Noreen Dhalla, N. Dhani, P. Dhingra, R. Dhir, Anthony Dibiase, Klev Diamanti, L. Ding, Shuai Ding, Huy Q. Dinh, L. Dirix, H. Doddapaneni, Nilgun Donmez, Michelle Dow, R. Drapkin, Oliver Drechsel, Ruben M. Drews, Serge Serge, T. Dudderidge, Ana Dueso-Barroso, Andrew J. Dunford, Michael Dunn, L. Dursi, F. Duthie, K. Dutton-Regester, Jenna Eagles, D. Easton, Stuart D. Edmonds, Paul A. Edwards, S. Edwards, R. Eeles, A. Ehinger, Juergen Eils, R. Eils, A. El-Naggar, Matthew Eldridge, K. Ellrott, S. Erkek, G. Escaramís, S. M. Espiritu, X. Estivill, D. Etemadmoghadam, J. Eyfjord, D. Fan, Yu Fan, W. Faquin, Claudiu Farcas, M. Fassan, A. Fatima, Francesco Favero, Nodirjon Fayzullaev, Ina Felau, S. Fereday, M. Ferguson, Vincent Ferretti, L. Feuerbach, M. Field, J. L. Fink, G. Finocchiaro, C. Fisher, M. Fittall, A. Fitzgerald, R. Fitzgerald, A. Flanagan, N. Fleshner, P. Flicek, J. Foekens, K. Fong, Nuno A. Fonseca, Christopher S. Foster, Natalie S. Fox, M. Fraser, Scott R. Frazer, Milana Frenkel-Morgenstern, William Friedman, J. Frigola, Catrina C. Fronick, Akihiro Fujimoto, M. Fujita, M. Fukayama, L. Fulton, R. Fulton, Mayuko Furuta, P. Futreal, Anja Füllgrabe, S. Gabriel, S. Gallinger, C. Gambacorti-Passerini, Jianjiong Gao, Shengjie Gao, Ø. Garred, Erik P. Garrison, D. Garsed, Nils Gehlenborg, J. Gelpí, J. George, D. Gerhard, C. Gerhauser, J. Gershenwald, Marc H. Gerstein, M. Gerstung, Mohammed Ghori, R. Ghossein, N. Giama, R. Gibbs, A. Gill, P. Gill, D. Giri, D. Głodzik, V. Gnanapragasam, Maria Elisabeth Goebler, M. Goldman, Carmen Gómez, Santiago Gonzalez, A. González-Pérez, D. Gordenin, J. Gossage, K. Gotoh, R. Govindan, D. Grabau, Janet S. Graham, R. Grant, A. Green, Eric D. Green, Liliana Greger, N. Grehan, Sonia Grimaldi, R. Grossman, A. Grundhoff, G. Gundem, Qianyun Guo, Manaswi Gupta, S. Gupta, I. Gut, M. Gut, Jonathan Göke, Gavin Ha, A. Haake, D. Haan, S. Haas, K. Haase, James E. Haber, Nina Habermann, Faraz Hach, Natsuko Hama, F. Hamdy, Anne Hamilton, M. P. Hamilton, Leng Han, George B. Hanna, M. Hansmann, N. Haradhvala, O. Harismendy, Ivon Harliwong, A. Harmanci, E. Harrington, Takanori Hasegawa, D. Haussler, Steve Hawkins, S. Hayami, Shuto Hayashi, D. Hayes, S. Hayes, N. Hayward, S. Hazell, Yao He, Allison P. Heath, S. Heath, D. Hedley, A. Hegde, David I. Heiman, Michael C. Heinold, Zachary J. Heins, Lawrence E. Heisler, E. Hellstrom-Lindberg, M. Helmy, Seong Gu Heo, Austin J. Hepperla, J. M. Heredia-Genestar, C. Herrmann, P. Hersey, J. Hess, H. Hilmarsdóttir, Jonathan Hinton, S. Hirano, N. Hiraoka, A. Hobolth, Ermin Hodzic, J. Hoell, S. Hoffmann, Oliver Hofmann, Andrea E. Holbrook, A. Holik, M. Hollingsworth, O. Holmes, R. Holt, Chen Hong, E. Hong, Jongwhi H. Hong, G. Hooijer, H. Hornshøj, F. Hosoda, Yong Hou, V. Hovestadt
98 28. 8. 2020.

Sex differences in oncogenic mutational processes

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.


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