Future wireless networks are expected to constitute a distributed intelligent wireless communications, sensing, and computing platform, which will have the challenging requirement of interconnecting the physical and digital worlds in a seamless and sustainable manner. Currently, two main factors prevent wireless network operators from building such networks: (1) the lack of control of the wireless environment, whose impact on the radio waves cannot be customized, and (2) the current operation of wireless radios, which consume a lot of power because new signals are generated whenever data has to be transmitted. In this paper, we challenge the usual “more data needs more power and emission of radio waves” status quo, and motivate that future wireless networks necessitate a smart radio environment: a transformative wireless concept, where the environmental objects are coated with artificial thin films of electromagnetic and reconfigurable material (that are referred to as reconfigurable intelligent meta-surfaces), which are capable of sensing the environment and of applying customized transformations to the radio waves. Smart radio environments have the potential to provide future wireless networks with uninterrupted wireless connectivity, and with the capability of transmitting data without generating new signals but recycling existing radio waves. We will discuss, in particular, two major types of reconfigurable intelligent meta-surfaces applied to wireless networks. The first type of meta-surfaces will be embedded into, e.g., walls, and will be directly controlled by the wireless network operators via a software controller in order to shape the radio waves for, e.g., improving the network coverage. The second type of meta-surfaces will be embedded into objects, e.g., smart t-shirts with sensors for health monitoring, and will backscatter the radio waves generated by cellular base stations in order to report their sensed data to mobile phones. These functionalities will enable wireless network operators to offer new services without the emission of additional radio waves, but by recycling those already existing for other purposes. This paper overviews the current research efforts on smart radio environments, the enabling technologies to realize them in practice, the need of new communication-theoretic models for their analysis and design, and the long-term and open research issues to be solved towards their massive deployment. In a nutshell, this paper is focused on discussing how the availability of reconfigurable intelligent meta-surfaces will allow wireless network operators to redesign common and well-known network communication paradigms.

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection. Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Two-dimensional semiconductors such as MoS2 are an emerging material family with wide-ranging potential applications in electronics, optoelectronics, and energy harvesting. Large-area growth methods are needed to open the way to applications. Control over lattice orientation during growth remains a challenge. This is needed to minimize or even avoid the formation of grain boundaries, detrimental to electrical, optical, and mechanical properties of MoS2 and other 2D semiconductors. Here, we report on the growth of high-quality monolayer MoS2 with control over lattice orientation. We show that the monolayer film is composed of coalescing single islands with limited numbers of lattice orientation due to an epitaxial growth mechanism. Optical absorbance spectra acquired over large areas show significant absorbance in the high-energy part of the spectrum, indicating that MoS2 could also be interesting for harvesting this region of the solar spectrum and fabrication of UV-sensitive photodetectors. Even though the interaction between the growth substrate and MoS2 is strong enough to induce lattice alignment via van der Waals interaction, we can easily transfer the grown material and fabricate devices. Local potential mapping along channels in field-effect transistors shows that the single-crystal MoS2 grains in our film are well connected, with interfaces that do not degrade the electrical conductivity. This is also confirmed by the relatively large and length-independent mobility in devices with a channel length reaching 80 μm.

Aims The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice. Design A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries. Methods Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. Results A total of 8261 patients (females 26%) were interviewed. Nineteen per cent smoked and 55% of them were persistent smokers, 38% were obese (body mass index ≥30 kg/m2), 59% were centrally obese (waist circumference: men ≥102 cm; women ≥88 cm) while 66% were physically active <30 min 5 times/week. Forty-two per cent had a blood pressure ≥140/90 mmHg (≥140/85 if diabetic), 71% had low-density lipoprotein cholesterol ≥1.8 mmol/L (≥70 mg/dL) and 29% reported having diabetes. Cardioprotective medication was: anti-platelets 93%, beta-blockers 81%, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers 75% and statins 80%. Conclusion A large majority of coronary patients have unhealthy lifestyles in terms of smoking, diet and sedentary behaviour, which adversely impacts major cardiovascular risk factors. A majority did not achieve their blood pressure, low-density lipoprotein cholesterol and glucose targets. Cardiovascular prevention requires modern preventive cardiology programmes delivered by interdisciplinary teams of healthcare professionals addressing all aspects of lifestyle and risk factor management, in order to reduce the risk of recurrent cardiovascular events.